The Science Behind Kambo

Kambo As a Peptide Therapy

The therapeutic effects of Kambo are derived from its rich content of bioactive peptides and neuropeptides. These compounds are beneficial to human health, offering a variety of health-enhancing effects.

Once absorbed into the body, they can help in disease prevention and the modulation of various physiological systems. The functions of these peptides span several bodily systems, including the gastrointestinal system, where they contribute to obesity prevention and promote feelings of fullness; the cardiovascular system, offering antihypertensive, antithrombotic, and cholesterol-lowering benefits; the immune system, providing antimicrobial and immune-modulating effects; and the nervous system, through opioid peptides that affect pain and mood regulation.

Why Supplement with Kambo?

As we age, our lifestyle choices start to impact our health, aligning with the evolutionary trend of declining vitality. This decline is essentially the result of human cells losing their ability to function as effectively as they did in our youth. Herein lies the significance of peptides, which are compounds comprising over 7,000 naturally occurring varieties within the human body, playing a pivotal role in cellular functions. However, as we age, the production of these peptides diminishes, leading to a state of confusion for our cells, essentially putting them into a dormant or "arrested" state. Kambo supplementation steps in to rejuvenate these systems, ensuring they operate smoothly once again. By providing cells with the necessary components to maintain efficiency, Kambo acts as a countermeasure to aging processes. A key aspect of restoring vitality is bolstering the immune system, equipping the body to fight viruses, illnesses, and diseases more effectively. In the context of the Covid era, maintaining a robust immune system is more important than ever. Kambo reinvigorates your immune system, equipping it with the resilience to combat health threats.

Kambo Research

Research on Kambo, the secretion from the Phyllomedusa bicolor frog, has garnered attention within the scientific community, particularly following its introduction to the U.S. by award-winning investigative journalist Peter Gorman and anthropologist Katharine Milton. Since then, several studies have explored Kambo's composition, its bioactive peptides, and their potential therapeutic applications. These studies delve into the diverse range of bioactive peptides present in Kambo, investigating their effects on various physiological and cellular processes.

The research examines how these peptides may contribute to pain relief, immune system modulation, anti-inflammatory effects, and potential benefits in treating infections and other health conditions. While the body of scientific literature on Kambo is growing, these studies represent the forefront of understanding Kambo's mechanisms of action and therapeutic potential.

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Bioactive and Antimicrobial Peptides in Kambo

  • PHYLLOMEDUSIN: These peptides trigger contractions in smooth muscle tissue and enhance secretions throughout the gastrointestinal tract, including the salivary glands, stomach, small and large intestines, pancreas, and gallbladder. They are primarily responsible for the 'deep purge' effect experienced following the Kambo administration.

  • PHYLLOKININ + PHYLLOMEDUSINS: Phyllokinin and phyllomedusins act as powerful vasodilators, enhancing the blood-brain barrier's permeability to facilitate their own entry, along with other active peptides. Additionally, they possess antimicrobial and antifungal characteristics.

  • CAERULEINS + SAUVAGINES: These peptides, comprised of 40 amino acids, exhibit myotropic effects on smooth muscles, leading to contractions in the colon and urinary bladder. They cause a reduction in blood pressure alongside an increase in heart rate. Additionally, they activate the adrenal cortex and pituitary gland, enhancing sensory perception and resilience. The peptides are notably powerful analgesics, boosting physical strength, the ability to endure pain, stress, and illness, while also reducing fatigue symptoms. Within the medical realm, these peptides aid in digestion and offer pain relief for conditions such as renal colic, pain from peripheral vascular insufficiency, and tumor-related discomfort.

  • DERMORPHIN + DELTORPHIN: Small peptides made up of 7 amino acids act as selective agonists for opiate receptors, demonstrating a potency 4000 times greater than morphine and 40 times stronger than naturally occurring endorphins.

  • ADENOREGULINS: These substances interact with the human body via adenosine receptors, which are crucial elements in all human cellular energy processes. These receptors present a potential target for addressing conditions such as depression, stroke, and cognitive disorders, including Alzheimer's Disease and Parkinson's Disease.

  • DERMASEPTINS: These peptides belong to a wide array of antimicrobial peptides that play a crucial role in the frog's defense mechanism against microbial invasions. They are notable for being the first vertebrate peptides identified to have deadly effects on filamentous fungi, which are known to cause severe opportunistic infections in cases of immunodeficiency syndrome or the use of immunosuppressive drugs. Furthermore, they exhibit lethal activity against a comprehensive range of bacteria, fungi, yeasts, and protozoa.

    Extensive research conducted at the University of Paris has demonstrated the effectiveness of the peptides Dermaseptin B2 and B3 in eradicating specific cancer cell types. In addition, a researcher from Queen's University in Belfast received a distinguished award for his innovative work in the field of cancer and Kambo. The mechanism through which it operates involves the inhibition of tumor cell angiogenesis, coupled with selective cytotoxicity towards these cells.

  • BRADYKININS: These peptides share structural and functional similarities with human bradykinin. They exhibit hypotensive properties by inducing vasodilation, which aids in the contraction of non-vascular smooth muscle, enhances vascular permeability, and is associated with the process of inflammatory pain.

  • BOMBESINS: These peptides enhance the production of hydrochloric acid by targeting the G cells in the stomach. Additionally, they boost pancreatic secretion, amplify intestinal myoelectric activity, and increase the contractility of smooth muscles.

  • CERULEANS: These compounds activate the secretion of gastric fluids, bile, and pancreatic juices, as well as stimulate specific smooth muscles. They hold potential for use in treating paralytic ileus and serving as a diagnostic tool for pancreatic dysfunction.

  • TRYPTOPHILINS: These neuropeptides, composed of 4-14 amino acids, are providing new insights into the functioning of the human brain.

Antimicrobial and Antiviral Effects

Numerous peptides present in Kambo exhibit antimicrobial and antiviral properties, serving primarily as a protective barrier on the frog's skin against parasitic fungi and other microorganisms in the jungle, which could easily penetrate and infect the frog.

The aforementioned peptides have been researched for their potential in combating challenging and drug-resistant bacteria and viruses, a situation that poses significant risks for patients with weakened immune systems. This vulnerability can stem from overall poor health or, more specifically, from immunodeficiency disorders.

Introduction of Kambo to the Western World

The Western scientific community first became aware of Kambo in the 1980s, thanks to the efforts of anthropologist Katherine Milton and journalist Peter Gorman, who lived with and studied the Kambo rituals of tribes in Peru and Brazil. They provided Kambo samples to biochemists, initiating the first study on the frog poison's biochemical composition. One notable biochemist involved was Vittorio Erspamer from the University of Rome, renowned for discovering serotonin. Erspamer, who dedicated much of his research to peptides, was intrigued by Kambo's potential to contain novel peptides with medical applications. Further significant research into Kambo was conducted in the 1990s by a team led by biochemist John Daly at the National Institute of Health in the US, where they identified and studied Adenoregulin, an antimicrobial peptide present in Kambo.

Kambo and The Future

Substantial efforts have been dedicated to unraveling the scientific and biochemical complexities of Kambo, resulting in at least 70 medical patents derived from its compounds. Yet, the journey into Kambo's potential is far from complete, with continuous research aimed at discovering and isolating additional compounds that could significantly benefit the medical community. Vittorio Erspamer, a pioneer in this field, hailed Kambo as "a fantastic chemical cocktail with potential medical applications unmatched by any other amphibian." Beyond the realm of science lies a deep reservoir of knowledge, cultivated over millennia by the indigenous tribes who first utilized Kambo in their rituals. Modern medical science has merely scratched the surface of Kambo's full potential for healing and health, hinting at the vast, yet-to-be-discovered wonders of this extraordinary natural remedy.